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Pediatric Acute Lymphoblastic Leukemia (pALL) is the most common type of leukemia diagnosed among children, with ~64,200 ALL cases diagnosed worldwide.1

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What is Pediatric
Acute Lymphoblastic
Leukemia (pALL)?

What is Pediatric Acute Lymphoblastic Leukemia (pALL)?

Pediatric Acute Lymphoblastic Leukemia (pALL) is a type of blood cancer that occurs when the bone marrow makes too many lymphocytes (a type of white blood cell). When this happens, there is less room for healthy white blood cells, red blood cells, and platelets in the blood.2

B cells, along with other cells, make up the body’s immune system.3 Cancerous B cells can cause a blood cancer called B-Cell Pediatric Acute Lymphoblastic Leukemia (pALL), which is the most common form of pediatric leukemia.4 Symptoms of pALL include being more prone to infections, anemic and bruising or bleeding easily.5

What is Pediatric Acute Lymphoblastic Leukemia (pALL)?

What are the treatment options for
Pediatric Acute Lymphoblastic Leukemia (pALL)?

In cancer care, the treatment options and recommendations depend on several factors, including the subtype and classification of Pediatric Acute Lymphoblastic Leukemia (pALL), possible side effects, age, and overall health. As treatment plans for Pediatric Acute Lymphoblastic Leukemia (pALL) vary from patient to patient, it is essential to discuss your child's unique case history and symptoms with your care team.
CHEMOTHERAPY

CHEMOTHERAPY

Chemotherapy often consists of a combination of several medications which help to stop the spread of fast-growing cancer cells.7

TARGETED THERAPY

TARGETED THERAPY

A type of treatment where specific parts of cancer cells are identified and blocked to prevent them from spreading.8 It can often be used alone or in combination with other therapies, such as chemotherapy or radiation therapy.

IMMUNOTHERAPY

IMMUNOTHERAPY

Patient’s immune system is enhanced using medicines to better recognise and treat cancer cells.9 This includes immune checkpoint inhibitors, immune system modulators, monoclonal antibodies, and T-cell therapy.

Chimeric Antigen Receptor (CAR) T-Cell Therapy

CAR-T cell therapy is a type of immunotherapy where CAR receptors used to treat cancer with altered immune cells. These specially altered white blood cells, called T cells, are modified to find and stop the spread of cancer cells in the body.10

RADIATION THERAPY

RADIATION THERAPY

High-energy radiation is used to treat cancer cells. It is an important step before a bone marrow or stem cell transplant.11

STEM CELL TRANSPLANT

STEM CELL TRANSPLANT

Impaired or diseased bone marrow is replaced with healthy cells from the patient’s own bone marrow or from a suitable donor.12

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What is CAR-T cell therapy?

CAR-T cell therapy harnesses the body’s natural defenses to treat cancer.13

CAR-T therapy involves altering your child’s own T cells, a type of white blood cell found in the immune system, with new chimeric antigen receptors (or CAR for short). When the CAR is combined with your child’s T cells, the CAR-T cell therapy enhances the body’s natural ability to treat cancer with reprogrammed T cells.
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DID YOU KNOW

10,000+ patients worldwide have already experienced CAR-T cell
therapy treatment

since the first FDA approved therapy was made available in 2017.14, 15

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When to consider CAR-T?

CAR-T cell therapy is an individualized treatment made from the body’s own T-cells. However, data shows that T-cell health will decline over time and result in poorer outcomes especially when additional treatments such as chemotherapy have been performed.

<strong>Potentially curative treatment for<br/> patients who are not responding well to<br/>initial treatments (refractory), or have diseases that came back (relapsed)</strong>

Potentially curative treatment for
patients who are not responding well to
initial treatments (refractory), or have diseases that came back (relapsed)

<strong>Harnesses the power of your child’s<br/>own T-cells to detect and treat<br/> cancerous B cells</strong>

Harnesses the power of your child’s
own T-cells to detect and treat
cancerous B cells

<strong>A one-time single infusion<br/> treatment either with or without<br/> hospitalization</strong>

A one-time single infusion
treatment either with or without
hospitalization

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Is CAR-T right for<br/> your loved one?

Is CAR-T right for
your loved one?

CAR-T cell therapy for Acute Lymphoblastic Leukemia treatment is a one-time, potentially curative, and innovative leukemia treatment option. It is approved worldwide (by the FDA since 2017 and over 30 other health authorities) for patients who have certain types of leukemia and lymphoma, including Pediatric Acute Lymphoblastic Leukemia (pALL) and Diffuse Large B-cell Lymphoma (DLBCL).

CAR-T MAY BE A SUITABLE OPTION
FOR PATIENTS WHOSE CANCER:

  • Has relapsed (went into recovery, then came back)
  • Is refractory (became resistant and non-responsive to standard leukemia treatment)

While the goal of CAR-T cell therapy is long-term recovery of cancer, it is important to note that not all patients will respond the same way to Acute Lymphoblastic Leukemia treatment.

If you are considering CAR-T cell therapy as a treatment for your child with relapsed or refractory Acute lymphoblastic leukemia, we are here to support you in managing their condition and helping you and your child on this treatment journey. Get information about approved treatment center locations, FAQs and more.

Find support here
Is CAR-T right for<br/> your loved one?
Hear the stories of Pediatric Acute Lymphoblastic Leukemia (pALL) patients and caregivers

Listen to the stories of
Pediatric Acute
Lymphoblastic Leukemia
(pALL) patients and their
caregivers

Hear the stories of Pediatric Acute Lymphoblastic Leukemia (pALL) patients and caregivers Learn More

References

  1. Dong, Y., Shi, O., Zeng, Q. et al. Leukemia incidence trends at the global, regional, and national level between 1990 and 2017. Exp Hematol Oncol 9, 14 (2020). https://doi.org/10.1186/s40164-020-00170-6

  2. Acute Lymphoblastic Leukemia (ALL), 2017 (5/17, G-CGT-1163553) – extracted from Novartis resource

  3. What is acute Lymphocytic leukemia (ALL)? (n.d.). Retrieved March 11, 2022, from Cancer.org website: https://www.cancer.org/cancer/acute-
    lymphocytic-leukemia/about/what-is-all.html

  4. Brown, P., et al. (2020). Pediatric acute lymphoblastic leukemia, version 2.2020, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network: JNCCN, 18(1), 81–112. doi:10.6004/jnccn.2020.0001

  5. Acute lymphoblastic leukemia (ALL). (n.d.-b). Retrieved March 11, 2022, from Kidshealth.org website: https://kidshealth.org/en/parents/all.html

  6. Leukemia – acute Lymphocytic – ALL – treatment options. (2012, June 25). Retrieved March 11, 2022, from Cancer.Net website: https://www.cancer.net/cancer-types/leukemia-acute-lymphocytic-all/treatment-options

  7. Chemotherapy for acute Lymphocytic leukemia (ALL). (n.d.). Retrieved March 11, 2022, from Cancer.org website: https://www.cancer.org/cancer/acutelymphocyticleukemia/treating/chemotherapy.html

  8. Targeted therapy for acute Lymphocytic leukemia (ALL). (n.d.). Retrieved March 11, 2022, from Cancer.org website: https://www.cancer.org/cancer/acute-lymphocytic-leukemia/treating/targeted-therapy.html

  9. Immunotherapy for Acute Lymphoblastic Leukemia (ALL). (n.d.). Retrieved March 11, 2022, from Cancer.org website: https://www.cancer.org/cancer/acute-lymphocytic-leukemia/treating/monoclonal-antibodies.html

  10. Research, & Markets. (2021, June 4). 2021 insights on the CAR-T cell therapy Global market – overview of clinical Trials. Research and Markets. https://www.globenewswire.com/en/news-release/2021/06/04/2241883/28124/en/2021-Insights-on-the-CAR-T-Cell-Therapy-Global-Market-Overview-of-Clinical-Trials.html

  11. Radiation therapy for childhood leukemia. (n.d.). Cancer.Org. Retrieved March 18, 2022, from https://www.cancer.org/cancer/leukemia-inchildren/treating/radiation.html

  12. What are stem cells? (n.d.). Retrieved March 11, 2022, from Cancer.org website: https://www.cancer.org/treatment/treatments-and-sideeffects/treatment-types/stem-cell-transplant/why-stem-cell-transplants-are-used.html

  13. CAR T-cell therapy and its side effects. (n.d.). Cancer.Org. Retrieved March 18, 2022, from https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/car-t-cell1.html

  14. Yescarta Patient Brochure – extracted from Novartis resource

  15. Kymriah Patient Numbers – extracted from Novartis resource

  16. Kymriah® (tisagenlecleucel), first-in-class CAR-T therapy from Novartis, receives second FDA approval to treat appropriate r/r patients with large B-cell lymphoma. (n.d.). Retrieved March 11, 2022, from Novartis website: https://www.novartis.com/news/media-releases/kymriah-tisagenlecleucel-firstclass-car-t-therapy-from-novartis-receives-second-fda-approval-treat-appropriate-rr-patients-large-b-cell-lymphoma